University of Pennsylvania

- Humanetics Corporation

Keith Cengel

Michael D Kaytor

Adam J Harvey

Eric Stanton Diffenderfer

Lawrence Dougherty

James J Pilla

Alireza Kassaee

Materials and methods for enhancing the effectiveness of proton radiation therapy (e.g., high linear energy transfer (LET) proton radiation therapy) against tumor cells are provided herein.

Sensitizing cells to proton radiation

Methods and apparatus are provided for applying low magnetic fields (&#x3c;400 G) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen dependent injuries that involve the radical pair mechanism. The magnetic fields are generated by fixed magnets or active magnets and used to enhance the survival of healthy cells during radiation treatment for cancer, to protect workers from radiation within nuclear power plants, to protect astronauts from radiation during long space voyages, to increase working time in exposed environments, to provide a safe room in hazardous locations, and to protect normal tissue during radiation treatment and in medical imaging modalities that use ionizing radiation (X-ray, CT, mammography). The method described herein may also be used to mitigate the damaging effects of reperfusion, stroke, oxygen toxicity, inflammation, autoimmune disease, and the like by applying protective magnetic fields.

Cell, tissue and organ protection using a magnetic field

Growing community of inventors

Bala Cynwyd, PA, United States of America

Keith Cengel