American Cyanamid Company

Other

Keith C Murdock

Frederick E Durr

Ving J Lee

Stanley A Lang, Jr

Thomas L Fields

Yang-I Lin

Paul Frank Fabio

Martin R Damiani

Richard L Webb

Ralph G Child

Janis Upeslacis

Martin L Sassiver

Patrick T Izzo

The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.

Anthracycline derivatives as solubilized pro-drugs

Quinolinecarboxylic acid derivatives as solubilized pro-drugs

The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, quanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.

Solubilized imidazole pro-drugs

Solubilized pro-drugs

The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.

N-acylated derivatives of bis(2-imidazolin-2-ylhydrazones) of 9,10-anthracenedicarboxaldehyde, useful as anti-cancer agents against certain strains in mice, are disclosed and described, including processes for manufacture and use.

Acylation products of bis(2-imidazolin-2-ylhydrazones) of

This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.

Novel 1,4-bis(substituted-amino(-5,8-dihydroxyanthraquinones and leuco

1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases

Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.

Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and

This disclosure describes a novel process for liberating the free bases of certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinones from the salts thereof.

Process for preparing certain

This disclosure describes compositions of matter useful for inducing the regression of transplanted tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of transplanted tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being 3,6-bis[2-(1-piperidino)ethoxy]acridine or the pharmacologically acceptable acid-addition salts thereof.

Method of treating transplanted tumors and modulating the immune response

1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases

This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.

1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases

This disclosure describes novel compositions of matter useful as growth inhibitors of transplanted tumors in mammals and the method of inducing the regression and/or palliation of leukemia and solid tumors in mammals therewith, the active ingredients of said compositions of matter being certain symmetrical 1,4-bis(substituted-amino)anthraquinones and the non-toxic acid-addition salts thereof.

Method of treating tumors in warm-blooded animals

This disclosure describes novel Schiff bases of 1,4-bis[(.omega.-aminoalkyl)amino]-9,10-anthracenediones and leuco bases thereof which are useful as chelating agents and for inducing regression of leukemia and/or inhibiting tumor growth in mammals.

Growing community of inventors

Pearl River, NY, United States of America

Keith C Murdock