Hewlett-packard Company

Agilent Technologies, Inc.

Keith C Butler

Peter G Webb

Karen W Shannon

Patrick James Collins

Sandra L Tang

Methods of identifying a sequence of a nucleic acid that is suitable for use as a surface immobilized probe for two or more mRNA transcripts encoded by the same gene are provided. In practicing the subject methods, a consensus region for the two or more transcripts is first identified, and this identified consensus region is then employed to identify the suitable nucleic acid sequence, e.g., by using a probe design protocol. The subject invention also includes algorithms for performing the subject methods recorded on a computer readable medium, as well as computational analysis systems that include the same. Also provided are nucleic acid arrays produced with probes having sequences identified by the subject methods, as well as methods for using the same.

Methods designing multiple mRNA transcript nucleic acid probe sequences for use in nucleic acid arrays

Apparatus for controlling the stepping of a pen and chart of a recorder is described in which the data is buffered so as to free up the processor. The pen steps as fast as it can and no new data points are read until the pen-stepping data is used up. The chart stepping is keyed to the reading of data points so that while the pen is moving to a desired position, the chart stands still.

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Newark, DE, United States of America

Keith C Butler