Imperial Chemical Industries Limited

Zeneca Limited

Keith Blakeney Mallion

George R Brown

Peter John Harrison, Deceased

David R Brittain

John David Pittam

Jean Bowler

Elwyn Peter Davies

Graham Ernest Robinson

Ralph W Turner

Dora N Richardson

Murdoch A Eakin

Paul Robert Whittamore

Nigel Philip Taylor

Alexander Henry Todd

Paul Robert Owen

Therapeutic amines

Process for preparing an antifungal azole with hydrazino and amidrazone

Biphenyl quinuclidines

Quinuclidine compounds of the formula I: ##STR1## R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen;

Heterocyclic derivatives

Quinuclidine derivatives as squalene synthase inhibitors

Quinclidine derivatives as squalene synthase inhibitors

Quinuclidine compounds useful in treating diseases

Heterocyclic compounds

The invention concerns pharmaceutially useful heterocyclic nitromethane compounds of the formula I: ##STR1## in which ring Q is a heterocycle of 4 to 7 ring atoms, the fragment completing the ring Q having 2 to 5 atoms, one of which is carbon, oxygen, sulphur or a group of the formula --NRa--, and the remainder are carbon; Ra is hydrogen, (1-6C)alkyl, (2-6C)alkanoyl, trifluoroacetyl, phenyl, benzoyl, or phenyl(1-4C)alkyl, the latter three optionally substituted; and R.sup.1 R.sup.2 and R.sup.3 are independently hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, phenyl, phenoxy or phenyl(1-4C)alkyl, the last three optionally substituted, or two of R.sup.1, R.sup.2 and R.sup.3 situated on adjacent ring carbon atoms and together with said carbon atoms form a benzene ring fused to ring Q, the benzene ring itself optionally substituted, provided that when the fragment completion ring Q is of 3 atoms then at least one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen; and salts thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds and of N-(nitromethylsulphonyl)morpholine for use in the treatment of diabetic complications.

Isoindoline nitromethane derivatives

The disclosure relates to a novel sequence of reactions for manufacturing known prostaglandin intermediates, and to novel chemical intermediates obtained in the course of the novel reaction sequence, for example methyl 5.beta.-chloro-2.beta.-dimethoxymethyl-3.alpha.-hydroxycyclopent-1.alpha.- ylacetate.

Cyclopentane acetic acid derivatives

The disclosure relates to a novel chemical process whereby enone intermediates for prostaglandins are reduced steroselectively to the .alpha.-enols, the .alpha.-hydroxy of which corresponds to the prostaglandin 15.alpha.-hydroxy group.

Chemical reduction process

The disclosure relates to a novel four-stage reaction sequence whereby known enone intermediates for prostaglandin analogues may be obtained from 4.beta.-dimethoxymethyl-2,3,3.alpha..beta.,6.alpha..beta.-tetrahydro-5.alp ha.-hydroxy-6.beta.-iodo-2-oxocyclopenteno[b]furan in substantially increased yield. A novel intermediate produced in the novel four-stage reaction sequence is also claimed.

Process for producing enone intermediates

The disclosure relates to new 2-aryloxymethylmorpholine derivatives which possess antidepressant properties, and to processes for the manufacture of the said morpholine derivatives, to pharmaceutical compositions containing them, and to a method of preventing or relieving depression in warm-blooded animals including man. Typical of the morpholine derivatives disclosed is 2-(o-ethoxyphenoxymethyl)morpholine.

Morpholine derivatives

The disclosure relates to novel intermediates, for use in the manufacture of known prostaglandins and prostaglandin-like compounds, for example aldehydes such as methyl 7-[2.beta.-formyl-3.alpha.-hydroxy-5.alpha.-(4-phenylbenzoyloxy)cyclopent- 1.alpha.-yl]hetp-5-cis-enoate and enones such as methyl 15-oxo-9.alpha.,11.alpha.-di(4-phenylbenzoyloxy)-5-cis,13-trans-prostadien oate, processes for their manufacture, and their conversion to prostaglandins or prostaglandin-like compounds.

Cyclopentylheptenoic acids and derivatives

Growing community of inventors

Knutsford, United Kingdom

Keith Blakeney Mallion