Glaxo Group Limited

Smithkline Beecham Corporation

Glaxosmithkline LLC

Glaxo Wellcome Inc.

Glaxosmithkline Intellectual Property Development Limited

Glaxosmithkline Intellectual Property (no.2) Limited

Glaxogrouplimited

Glaxosmithkline Intellectual Property Limited

Keith Biggadike

Diane Mary Coe

Steven John Coote

Stephen Allan Smith

Panayiotis Alexandrou Procopiou

Brian Edgar Looker

Deborah Needham

Rosalyn Kay Nice

Charlotte Jane Mitchell

Xiao Qing Lewell

Naimisha Trivedi

Paul Spencer Jones

Stephen Barry Guntrip

Jeremy John Payne

Victor Witold Jacewicz

Andrew Simon Craig

Daniel Terence Tape

Michael John Millan

Aurelie Cecile Champigny

John Frederick Seager

Anthony William James Cooper

Rajnikant Patel

David House

Dean David Edney

Michael John Monteith

Rebecca Jane Moore

Andrew L Theophilus

Amyn Sayani

Ian Buxton

Kenton Reed

Abigail Halton

Alan D Borthwick

Richard Storer

Brian Noga

Iain McFarlane McLay

Barrie E Kirk

Duncan Stuart Holmes

David Malcolm Crowe

Simon John Fawcett MacDonald

Philip Charles Box

Gordon G Weingarten

Niall G Weir

Gianpaolo Bravi

Matthew Peter John

Philip Alan Skone

Anthony D Baxter

Ian Richard Buxton

Derek Norman Evans

Amyn Pyarali Sayani

Chi L Mo

Kenton Lewis Reed

Rita Field

Grahame Robert Woollam

Olga Chetina

Rosanne Mary Farrell

Ian L Paternoster

David A Borthwick

Leslie Stephenson

Andrew Lewis Theophilus

Gordon Gad Weingarten

Avinash Chander Sharma

Simon John Fawcett Macdonald

A compound of formula (1) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer and as vaccine adjuvants.

Cyclic di-nucleotides as modulators of STING

Compounds of formula (I) and salts thereof: wherein Ris hydrogen, methyl or &#x2014;(CH)OR, Ris methyl or &#x2014;(CH)OR, or Rand R, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; Rand Rare each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon

Compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

6-amino-purin-8-one compounds

A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

Cyclic dinucleotides useful for the treatment of inter alia cancer

The present invention relates to compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

A compound of formula (I) wherein or a pharmaceutically acceptable salt thereof.

N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists

The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.

Compounds

The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.

Glucocorticosteroid compound having anti-inflammatory activity

According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.

Anti-inflammatory androstane derivative

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Stevenage, United Kingdom

Keith Biggadike