Cellphire, Inc.

Keith Andrew Moskowitz

Amber Nicole Lee

Braden Carl Ishler

Rafael Jorda

William Matthew Dickerson

Glen Michael Fitzpatrick

Narendra Nath Tandon

Michael Alexander Mathews

Stephen Edward Amos

Daniel Allen Sheik

Joshua Donald Montgomery

Shan Xu

Alan S Rudolph

David G Ho

Cindy S Orser

Joshua Dee

Ying Yi Zheng

David Ho

In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Thrombosomes as an antiplatelet agent reversal agent

Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Platelets as delivery agents

Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Platelet derivative compositions, and pluralities of containers containing same

Methods using freeze-dried platelet derivative compositions for restoring hemostasis in a subject

Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Treatment of von Willebrand disease

Methods of treating bleeding in a subject treated with an antiplatelet agent

In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Platelets loaded with anti-cancer agents

Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Materials and methods for producing blood products

Growing community of inventors

Westfield, IN, United States of America

Keith Andrew Moskowitz