Roche Palo Alto LLC

Syntex (u.s.a.) Inc.

Other

Keith Adrian Murray Walker

Francisco Javier Lopez-Tapia

Sharon Marie Dankwardt

Jian Jeffrey Chen

Jeffrey Allen Campbell

Shu-Hai Zhao

Chris Allen Broka

Christine E Brotherton-Pleiss

Joan Marie Caroon

Jacob Berger

Nancy Delaet

Roland Joseph Billledeau

Leslie Ann Robinson

Dov Nitzan

Harold Edgar Van Wart

Arlindo Lucas Castelhano

Ralph New Harris, Iii

David Bruce Repke

Russell Stephen Stabler

Michael J Melnick

Nancy Elisabeth Krauss

Bradley E Loe

Robert Than Hendricks

Pankaj D Rege

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

[1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Dihydropyrimidone amides as P2X7 modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

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Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Dihydropyridone amides as P2X7 modulators

This invention relates to compounds of Formula (I)wherein R-R, A, Z and n are as described in the Summary of the Invention that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for their preparation.

Peptidic procollagen C-proteinase inhibitors

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Sulfonamide hydroxamates

Sulfonamide compounds

Sulfamide-metalloprotease inhibitors

Growing community of inventors

Los Altos Hills, CA, United States of America

Keith Adrian Murray Walker