Hoffmann-la Roche Inc.

Keith A Yagaloff

Noal Cohen

Ferdinand K Lee

Li Chen

Waleed Danho

Xin-Jie Chu

Adrian Wai-Hing Cheung

Joseph Swistok

Andrzej Robert Daniewski

Yao Wang

Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity

Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed. In one embodiment, the peptides are of formula I:

Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity

The invention relates to compounds selected from the group consisting of the formulas: ##STR1## wherein R.sup.2 and Ph are as described herein. These compounds are potent leukotriene B.sub.4 antagonists and are therefore useful in the treatment of inflammatory diseases.

Carboxylic acid Leukotriene B4 antagonists

Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ; Y is O, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, or --OCH.sub.2 C.sub.6 H.sub.4 --;

Carboxylic acid leukotriene B.sub.4 antagonists

Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ;

Growing community of inventors

Hohokus, NJ, United States of America

Keith A Yagaloff