May & Baker, Ltd.

Keith A Stuttle

David J Lythgoe

Garry Fenton

Christopher Smith

Michael J Ashton

David Riddell

Andrew W Bridge

Christopher G Newton

Donald I Dron

Robert K Chambers

Neil Victor Harris

Michael P Caton

Barbara Joyce Broughton

Ian Michael McFarlane

Edward Lunt

Libert C Saunders

Peter J Warne

David W Gilmour

Adnan H Al-Shaar

Diane M Kelsey

Ian McClenaghan

Peter Lowden

Duncan C McDougall

Malcolm P Toft

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

Therapeutically useful pyrrolo[2,1-a]phthalazine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represent cycloalkyl, optionally substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Pyrrolophthalazines

Ethene derivatives

Compounds of the general formula: ##STR1## wherein R.sup.1 represents a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms or a phenoxy or benzyl group, and pharmaceutically acceptable salts and esters thereof, possess pharmacological properties of use in the fields of mammalian reproduction and cardiovascular disease.

Bicycloheptane derivatives

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Rockford, United Kingdom

Keith A Stuttle