Washington University

Barnes Jewish Hospital

Celgene Corporation

Barnes-jewish Hopital

Hruska, Keith

Fang, Yifu

Sloan, Victor Schorr

Keith A Hruska

Magdalena Wozniak

William Allen Smith

Randall Stevens

Victoria Sung

William H Smith

Yifu Fang

Victor Schorr Sloan

Eric T Choi

Randall L Duncan

Elizabeth L Barry

Peter A Friedman

Nianhang Chen

William Smith

Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Activin-ActRII antagonists and uses for treating bone and other disorders

The present invention relates to prevention and treatment of vascular sclerosis, vascular calcification (VC) and neointimal hyperplasia using a morphogen.

BMP-7 for use in treating neointimal hyperplasia

An isolated and essentially purified cell matrix plaque of initial bone formation comprising of &agr; &bgr; integrin and rapid assays using such cell matrix plaques to measure potentials of factors, regimens or tissues for stimulation and/or inhibition of bone formation.

Cell matrix plaques of initial bone formation

An isolated and essentially purified cell matrix plaque of initial bone formation comprising of &agr;,&bgr;,integrin and rapid assays using such cell matrix plaques to measure potentials of factors, regimens or tissues for stimulation and/or inhibition of bone formation.

An antisense oligonucleotide of 10 to 35 nucleotides in length that can hybridize with a region of the .alpha..sub.1 subunit of the SA-Cat channel gene DNA or mRNA is provided, together with pharmaceutical compositions containing and methods utilizing such antisense oligonucleotide.

Voltage-gated calcium channel and antisense oligonucleotides thereto

Growing community of inventors

St. Louis, MO, United States of America

Keith A Hruska