Intel Corporation

Novartis Ag

Sirna Therapeutics, Inc.

Keith A Bowman

Chandra Vargeese

James W Tschanz

Vivek K De

Shih-Lien L Lu

Nam Sung Kim

Jeremy Lee Baryza

Junping Zhao

Laura Ellen West

Tanay Karnik

Rohan Eric John Beckwith

Thomas Zabawa

Ritesh Bhanudasji Tichkule

Gabriel Grant Gamber

Tanzina Fazal

Cameron Chuck-munn Lee

Janice C Lee

Shuangxi Wang

Crystal Byers

Christopher B Wilkerson

Jaydeep P Kulkarni

Chris Wilkerson

Christopher Shaffer

Andrew John Geall

Carlos Alfonso Tokunaga

Cameron Lee

Noah Gardner

Travis Jeannotte

Tanzina Labonte

James Tachanz

Tanay Karnlk

Rohan Eric Beckwith

Cameron Chuck-Munn Lee

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Lipids and lipid compositions for the delivery of active agents

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

Method of encapsulating a nucleic acid in a lipid nanoparticle host

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues. 

Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Sequential circuit with error detection

The disclosed system and method detect and correct register file read path errors that may occur as a result of reducing or eliminating supply voltage guardbands and/or frequency guardbands for a CPU, thereby increasing overall energy efficiency of the system.

Resilient register file circuit for dynamic variation tolerance and method of operating the same

Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.

Lipids, lipid compositions, and methods of using them

An aging monitor circuit that provides a more accurate estimate of aging and/or delay in a circuit and/or circuit path. The aging monitor circuit employs a separate aging path with driving and receiving flip flops (FFs) and a tunable replica circuit (TRC) to enable measurements of single-transition DC-stressed path delay that only propagates through stressed transistors or other circuit element(s). A finite state machine (FSM) in the aging monitor circuit is configured to adjust a frequency of a clock signal output by a digitally controlled oscillator (DCO) in response to an error signal output by the receiving FF. The error signal is generated in response to single-transition DC-stressed path delay; and therefore enables the adjustment of the frequency of the dock signal to correspond to an amount or effect of the delay.

Self-contained, path-level aging monitor apparatus and method

Method for synthesis, deprotection, and/or purification of nucleic acid molecules, such as oligonucleotides comprising one or more ribonucleotides. Such nucleic acid molecules include siRNA, dsRNA, ribozymes, antisense, and aptamers.

Deprotection and purification of oligonucleotides and their derivatives

Growing community of inventors

Hillsboro, OR, United States of America

Keith A Bowman