Kyorin Pharmaceutical Co., Ltd.

Keita Miyoshi

Yasushi Kohno

Kiyoshi Fujii

Momoko Taru

Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives represented by general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), Ris a hydrogen atom or the like; Ris an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like; X is a methylene group which may be substituted with one or two fluorine atoms, or the like; Y is a hydrogen atom or the like; and Z is a halogen atom. 

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Tochigi, Japan

Keita Miyoshi