Daiso Co., Ltd.

Keisuke Yaegashi

Yoshiro Furukawa

Yasushi Miki

Kazumasa Hinoue

Hiroshi Yoshimoto

Yoshifumi Nagano

Shingo Iwashina

The invention relates to a production method of a 2-hydroxymethylmorpholine salt, which includes crystallization from a solution containing 2-hydroxymethylmorpholine of formula (1)  

Process for producing 2-hydroxymethylmorpholine salt

A process for producing a glycidyl ether and an optically active compound thereof with high yield and an optically high purity comprising reacting an alcohol with epihalohydrin in a base to thereby produce a glycidyl ether, the reaction performed in a two-layer system of a nonaqueous organic solvent and an aqueous solvent.

Process for producing glycidyl ether

A process for preparing regioselectively an optically active 1-halogeno-2-hydroxypropyl compound of the following formula;

Process for preparation of optically active halogeno hydroxypropyl compound and glycidyl compound

The present invention relates to a process for reacting &agr;-aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active &agr;-aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.

Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives

An industrial process for preparing an oxazolidin-2-one derivative represented by the following general formula (3)

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Osaka, Japan

Keisuke Yaegashi