Shionogi Company Limited

Keisuke Tonogaki

Manabu Katou

Nobuyuki Tanaka

Eiichi Kojima

Masahiko Fujioka

Masafumi Iwatsu

Akira Ino

Naoki Ohyabu

Yu Hinata

Hiroshi Yoshida

Kenji Takaya

Masahiro Sakagami

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof,

Azabenzimidazole derivative having AMPK-activating activity

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: 

Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula:   

Hetero ring-fused imidazole derivative having AMPK activating effect

The present invention discloses novel cyclohexane derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), or a pharmaceutically acceptable salt or a solvate thereof: wherein A is substituted or unsubstituted aryl or heterocyclyl; a combination of X and Y is a combination selected from (X, Y)&#x2550;(C(&#x2550;O)N(R), C(&#x2550;O)N(R)), (C(&#x2550;O)N(R), imidazole-1,3-diyl), (N(R), C(&#x2550;O)N(R)), (O, C(&#x2550;O)N(R)), (C(R)(R), N(R)) or (a single bond, C(&#x2550;O)N(R)); R, Rand Rare independently hydrogen or substituted or unsubstituted alkyl; Ris substituted or unsubstituted aryl or heterocyclyl; Ris halogen, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy; m is 0 or 1; and n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or fused bicyclic heterocycle.

Cyclohexane derivative having NPY Y5 receptor antagonism

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Osaka, Japan

Keisuke Tonogaki