Glytech, Inc.

Keisuke Tazuru

Kazuhiro Fukae

Masatoshi Maeda

Hirofumi Ochiai

Taiji Shimoda

Kenta Yoshida

Katsunari Tezuka

Kazuyuki Ishii

Takashi Tsuji

Yasuhiro Kajihara

Izumi Sakamoto

Hayato Saijo

The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon &#x3b2; activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon &#x3b2; activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

Glycosylated polypeptide and pharmaceutical composition containing same

The object of the present invention is to provide a sugar chain-polypeptide complex that may form a transparent and homogeneous hydrogel in a broad pH. The present invention provides a sugar chain-polypeptide complex, characterized in that said polypeptide is a polypeptide comprising an amino acid sequence consisting of 8-34 amino acid residues in which polar and nonpolar amino acid residues are alternately arranged, and one or more sugar chains are bound to said polypeptide.

Sugar chain-polypeptide complex

[Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analog thereof being replaced with a glycosylated amino acid.

Glycosylated polypeptide and drug composition containing said polypeptide

[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analog thereof being replaced by glycosylated amino acids.

[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids.

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Kyoto, Japan

Keisuke Tazuru