Hitachi, Ltd.

Fuji Jukogyo Kabushiki Kaisha

Showa Denko Materials Co., Ltd.

Hitachi Plant Services Co., Ltd.

Keisuke Shibuya

Yasuyuki Ukon

Hiroshi Yoshida

Toshiaki Matsuo

Ryoichi Haga

Yasuhiko Tada

Takeyuki Kondo

Kenichiro Oka

Yuzuru Shimazaki

Ken Amano

Masashi Maruyama

Sei Murakami

Masaru Nanba

Yui Sugita

Masaru Namba

Ryouichi Haga

Kenichirou Oka

Takeyuki Kondou

Nanae Yamashita

A method and apparatus for screening of cell lines and culture conditions includes a target value setting step that sets a target value relating to a metabolic reaction of a culture cell; a first culturing step; an analysis step; an analysis value calculation step that performs a metabolism analysis based on an analysis result from the analysis step and calculates an analysis value; a culture condition computation step that computes, using a correlation model, a culture condition giving an analysis value most close to the target value, and modifies the culture condition set in the first culturing step to the computed culture condition; a second culturing step that cultures a cell under the modified culture condition; and a screening step.

Method and apparatus for screening of cell strains and culture conditions

An object of the present invention is to provide an adsorbent material having high dispersibility and reversibility. The adsorbent material has a polymer material having a plurality of functional groups ionizable in water and exhibiting no lower limit critical solution temperature, an adsorption site capable of interacting with a target substance, and a carrier.

Adsorbent material

In order to improve variety of medicines producible, a central control device that controls a plant control device for controlling a cell culture environment of a cell strain for producing a medicine is installed in a pharmaceutical manufacturing plant for manufacturing a medicine. The central control device controls the plant control device on the basis of analysis data relevant to an inspection result of a patient. The central control device transmits traffic information to a navigation device, and the navigation device searches for a delivery route of a delivery vehicle for delivering a medicine on the basis of the transmitted traffic information.

Medicine production support system and medicine production support method

An object of the present invention is to separate a material to be separated at a low cost and constant accuracy when the material to be separated is separated from a mobile phase containing the material to be separated through the passing of the mobile phase through a stationary phase, even if the mobile phase has a large volume. A separation device characterized in that a separation column provided with a stationary phase having a volume capable of processing the entire volume of a mobile phase containing a material to be separated is provided, the separation column is replaceable, and the usage count of the stationary phase reaches a lifetime count through the processing of one batch.

Separation device and separation method

This invention provides a culture control method and a cell culture apparatus that enable stable cell culture by regulating shear stress to be applied to cells within an adequate range. With the application of such culture control method and cell culture apparatus, cell culture is performed under agitation culture conditions in which the shear stress distribution is 0.5 Pa to 20 Pa in 80% or more of the culture vessel by volume.

Culture control method, cell culture apparatus, and apparatus for evaluation of cellular characteristics

Provided is a purification device for purifying a useful substance (i.e., target substance) without using an acidic eluent. The purification device purifying the target substance comprises a column and a filler packed in the column. The filler contains a carrier, a temperature responsive polyamino acid bonded to the carrier, and a binding substance bonded to the temperature responsive polyamino acid and specifically bonding to the target substance.

Purification device, and purification method

A transmission includes an input shaft to receive a rotation of an engine, drive gears respectively attached to the input shaft to freely rotate individually, an output shaft disposed parallel to the input shaft in order to output rotation following a gear shift, driven gears respectively attached to the output shaft to freely rotate individually and to mesh with the drive gears, an engagement mechanism to fix a gear to be used in a gear shift individually, from among the drive gears, to the input shaft to be incapable of relative rotation, and a selector mechanism to fix, during the gear shift, the driven gear of a corresponding gear position individually, which meshes with the drive gear fixed to the input shaft by the engagement mechanism, to the output shaft to be incapable of relative rotation, and a hub that is fixed to the input shaft.

Transmission

A transmission includes an input shaft to receive the rotation of an engine, drive gears attached to the input shaft so as to freely rotate, an output shaft to output rotation following a gear shift, driven gears that are attached to the output shaft so as to freely rotate and mesh with the drive gears, an engagement mechanism to fix a gear to be used in a gear shift, from among the drive gears, to the input shaft to be incapable of relative rotation prior to a gear shift, and a selector mechanism to fix, during the gear shift, the driven gear of a corresponding gear position, which meshes with the drive gear fixed to the input shaft by the engagement mechanism, to the output shaft to be incapable of relative rotation.

A crankshaft of an engine is coaxially connected with a main shaft of a transmission through an input shaft. In the transmission, a counter shaft is incorporated below and in parallel with the main shaft. There are provided a main transmission and a sub transmission between the main shaft and the counter shaft. The driving force of the engine is divided into a front driving force and a rear driving force by a center differential and the front driving force is transmitted from the counter shaft to front wheels through a front drive shaft incorporated below and in parallel with the counter shaft and a front differential. The rear driving force is transmitted to rear wheels through a rear drive shaft and a rear differential.

Growing community of inventors

Tokyo, Japan

Keisuke Shibuya