Nissan Chemical Industries Limited

Keisuke Ohdoi

Mikio Suzuki

Ryozo Sakoda

Hiroo Matsumoto

Yoshio Ohara

Nobuhide Miyachi

Kiyotomo Seto

Kazuhiko Ohrai

Ken-ichi Shikada

Yoshimasa Kamikawaji

Yukinori Masuda

Takashi Yotsumoto

Takeshi Naito

Tetsuya Kobayashi

Katsuhiro Kato

The present invention provides novel pyridine type thiazolidines and their salts, expressed by the following formula (I): ##STR1##

Pyridine type thiazolidines

A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.

Pyranobenzoxadiazole derivatives

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Funabashi, Japan

Keisuke Ohdoi