Canon Kabushiki Kaisha

National Institute of Advanced Industrial Science and Technology

Artemis, Inc.

Keisuke Makino

Tadashi Okamoto

Yoshinori Tomida

Nobuko Yamamoto

Masahiro Kawaguchi

Akira Murakami

Hiroyuki Inoue

Akinori Matsushika

Shigeki Sawayama

Tsutomu Kodaki

Seiya Watanabe

Toshiyuki Arai

Kenjiro Mori

Genetic recombinant yeast expressing xylose reductase (XR), (wild-type or mutant) xylitol dehydrogenase (XDH), and xylulokinase (XK) and a method for highly efficiently producing ethanol from xylose using the yeast are provided.-derived XR and (wild-type or modified-type) XDH genes and-derived XK gene were introduced via chromosomal integration. Thus, a genetic recombinant yeast having a high xylose fermentation rate, being capable of producing ethanol from xylose in high yields, and having high xylose fermentability in the presence of glucose, as well as a method using the recombinant yeast for highly efficiently producing ethanol from xylose or a saccharified solution from lignocellulose-based biomass are provided. Furthermore, a method for improving the xylose fermentability of the genetic recombinant yeast of the present invention via acclimatization treatment is also provided herein.

Hexose-pentose cofermenting yeast having excellent xylose fermentability and method for highly efficiently producing ethanol using the same

Active oxygen scavengers containing pterin derivatives

A method for detecting a nucleic acid hybrid comprises steps of adding a nucleic acid probe into a sample solution containing a targeted nucleic acid, and detecting a double helical structure of a hybrid formed between the probe and the targeted nucleic acid, wherein the step for detecting the double helical structure comprises incorporating, into the sample solution, two or more kinds of reagents which are capable of causing a detectable change by interaction therebetween through the double helical structure and measuring the change caused by the interaction of the reagents; and at least one of the two or more kinds of reagents is joined to the probe.

Detection of nucleic acid hybrid variation which interacts with double

A method for detecting a target nucleic acid comprises the steps of reacting a sample with a probe in the presence of two or more kinds of reagents capable of being made an irreversible change capable of being detected and accumulating by an interaction through a double helix structure under a condition enabling the replication of the formation and dissociation of a hybrid composed of the target nucleic acid in the sample and the probe, accumulating the irreversible change caused by the interaction of the reagents, and then detecting the accumulated change.

Method for detecting a target nucleic acid by using an interaction of

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Kyoto, Japan

Keisuke Makino