Public University Corporation Nagoya City University

The University of Tokyo

Keisuke Katsushima

Yutaka Kondo

Kazunori Kataoka

Kanjiro Miyata

Hyun Jin Kim

This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.

Antitumor drug delivery formulation

This invention provides a composition and a method for treating or preventing a subject having a tumor that more highly expresses a TUG1 gene than in normal tissues (e.g., brain tumor, breast cancer, colon cancer, prostate cancer, liver cancer, lung cancer, leukemia, or lymphoma), which composition comprises, as an active ingredient, a nucleic acid that inhibits the high expression of the TUG1 gene in tumor stem cells.

Growing community of inventors

Nagoya, Japan

Keisuke Katsushima