Kyowa Hakko Kogyo Kabushiki Kaisha

Ihara Chemical Industry Co., Ltd.

Ihara Chemical Kogyo Kabushiki Kaisha

Keisuke Isozumi

Kazuhiro Kubo

Shunji Ichikawa

Joji Nakamura

Toyofumi Yamada

Hajime Takahashi

The present invention provides a process for producing an amic acid ester represented by the following general formula (7) (wherein A is substituted or unsubstituted lower alkylene or the like; R is substituted or unsubstituted lower alkyl or the like; and R is hydrogen or lower alkyl), which process comprises reacting, in the presence of water, an amino acid represented by formula (1) with a halogenated carbonic acid ester represented by formula (2) (wherein X is halogen) to form an amide compound represented by formula (3), then reacting the amide compound with a halogenated carbonic acid ester represented by formula (4) (wherein R is substituted or unsubstituted lower alkyl or the like; and X is halogen) to form, in the system, a mixed acid anhydride represented by formula (5), and reacting the mixed acid anhydride with an amine compound represented by formula (6) (wherein Het is substituted or unsubstituted heterocyclic).

Process for preparing amic acid esters

Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;

Agent for cerebral protection

Cinnamoyl piperidines and thiomorpholine and cerebral protection

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Shizuoka, Japan

Keisuke Isozumi