Ono Pharmaceutical Co., Ltd.

Keisuke Hanada

Kousuke Tani

Atsushi Naganawa

Masaki Asada

Akihiro Kinoshita

Satonori Higuchi

Yasuhiro Takeda

Atsushi Shimabukuro

Takahiro Nekado

Yoshiyuki Aratani

An object of the present invention is to provide a DP receptor antagonist. A compound represented by general formula (I): 

DP antagonist

A compound that can be a therapeutic agent for underactive bladder which has low risk of side effects and can be administered orally is provided. Furthermore, a crystal which is advantageous in view of the stability, long-term storage, handleability, easiness of the drug preparation or the like as a drug substance of medicaments is provided. Since a salt of 2-[(2-{(1R,5R)-2-oxo-5-[(1E,4S)-7,8,8-trifluoro-4-hydroxy-4-methyl-1,7-octadien-1-yl]cyclopentyl}ethyl)thio]-1,3-thiazole-4-carboxylic acid or a diastereomeric mixture thereof and 4-piperidinemethanol is a chemically very stable crystal, it can be stored for a long time, and is very useful as a drug substance of medicaments.

Amine salt and crystals thereof

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Osaka, Japan

Keisuke Hanada