Toray Industries, Inc.

Keishi Miwa

Yoshihiro Naruse

Shuichi Nonaka

Kakuji Murakami

Mayumi Fukuyama

Kazuo Ishikawa

Satoshi Kondo

KaKuji Murakami

Takehiko Uchiyama

Rumiko Ishii

A spongelike structure or a powder having fibers three-dimensionally arranged therein with high dispersibility, whose apparent density can be designed depending on the purpose or utility, as well as a process producing it. A fiber dispersion in which fibers having a number mean diameter in a predetermined range are dispersed in a dispersion medium, and this fiber dispersion is dried to remove the dispersion medium, thereby, a spongelike structure and a powder are produced.

Process for producing spongelike structure

This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as &ldquo;MHC class II&rdquo; for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials in which MHC class II, &agr; and/or &bgr; subunit of MHC class II, or a part thereof is bound to a carrier such as beads, fibers and hollow fibers via covalent bond, as well as a module for removing superantigen using the same. This invention also provides a method for detecting or quantifying superantigens using MHC class II or a part thereof having an affinity to the superantigens, as well as an assay kit therefor.

Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound

A material having affinity for LTA and/or PrA and/or aHL and/or proteinase is prepared by introducing functional groups capable of hydrogen bond formation into a substrate. Using this material, LTA and/or PrA and/or aHL and/or proteinase in blood, plasma or other solution of high protein concentration can be rapidly detoxified or removed. Articles for LTA and/or PrA and/or aHL and/or proteinase removal of detoxification using this material are described, in particular a body fluid purification column for LTA and/or PrA and/or aHL and/or proteinase removal and an LTA and/or PrA and/or aHL and/or proteinase-adsorptive dressing.

Bacterial-derived component removal material

A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provided is a body fluid purifying column for eliminating or detoxification of super antigens. In addition to that, this invention provides a wound dressing material with super antigen adsorbing properties.

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Takatsuki, Japan

Keishi Miwa