Material Engineering Technology Laboratory, Incorporated

Terumo Kabushiki Kaisha

Terumo Corporation

Material Engineering Technology Lab., Inc.

Mateial Engineering Technology Laboratory, Incorporated

Keinosuke Isono

Tatsuo Suzuki

Takao Yoshida

Keiji Naoi

Hiroyuki Shichi

Akira Igari

Hiroshi Motobayashi

Masami Ishida

A container for therapeutic use is formed of a main body, which is made of a flexible resin and provided with a bag portion. The bag portion is formed in a flat shape at at least a part thereof where mutually-opposing walls of the bag portion are peelably welded together at inner surfaces thereof to form a welded region. A hole is formed as an attachment hole through at least one of the mutually-opposing walls in the welded region. A holder with a medicament placed therein, said medicament being prone to a change in property or color upon absorption of moisture, is hermetically attached to the at least one wall over the attachment hole to seal the medicament in the holder. A moisture-barrier member with a desiccant placed therein is arranged on a side opposite to the holder so that the other wall of the bag portion is hermetically covered by the moisture-barrier member at a position at least corresponding to the attachment hole.

Container for therapeutic use

A medical container with an electrolyte solution stored therein is disclosed. It is formed of a resinmade container main body, a base solution compartment, at least one isolated compartment or connected compartment, and an openable portion. The base solution compartment is arranged in the container main body and is filled with the electrolyte solution in a state steamsterilized together with the container main body. The isolated compartment or connected compartment is arranged in the container main body, is isolated from the base solution compartment by an isolation wall interposed therebetween, and is filled with a bicarbonate. The openable portion permits aseptic communication between the base solution compartment and the isolated compartment or connected compartment by an operation from an outside of the container main body at the time of use. The openable portion is formed at at least a part of the isolation wall. This medical container makes it possible to store an electrolyte solution, dialysate or the like at a pH value close to that of the body fluid without inducing kidney problems, diarrhea, vomiting or the like due to acidosis or the like upon use.

Medical container with electrolyte solution stored therein

An instillator having a medicator-connecting mouth into which a medication that cannot be subjected to sterilization may be introduced by a simple operation and in a germ-free condition so that the medication is mixed with a pharmaceutical liquid contained therein, said instillator being composed of an outlet member, a medicator-connecting mouth and a body, said medicator-connecting mouth comprising a communicating pathway which communicates with the inside of the body upon use, a germ-trapping filter disposed in the middle of said communicating pathway, a sealing means for sealing said communicating pathway disposed between said germ-trapping filter and said body, and a connecting means disposed at one end of said communicating pathway opposite to the body, the body made of a flexible material being filled with a pharmaceutical liquid, sealed and subjected to autoclaved sterilization, the connecting port of the instillator having a connecting duct tightly fitted into the port.

Instillator with medicator-connecting mouth

A therapeutic container is provided for use in a closed therapy system. The therapeutic container is a flexible container that has suspending means, that is divided into a first compartment and a second compartment by an isolation zone, that has an outlet member provided with an openable communication passage which permits communication between the first and second compartments, and that optionally has a second openable communication passage at a location proximal to the end of the container on the side of the suspending means, whereby both the contents of the first and the second compartments can be discharged through the outlet member at a constant mixing ratio while mixing them together.

The present invention provides a stopper device comprising a stopper-support structure having a passage inside and a stopper accommodated in the-passage so as to block the passage but movably in the passage, as well as an apparatus containing the stopper device, used for mixing of two components. The stopper device can be penetrated with a connecting device with no edge and therefore generates no debris during penetration and reliably prevents leakage of container contents.

Stopper device for container and mixing apparatus using the same

An apparatus is provided for separately storing and selectively mixing a first component, which is in a liquid form, and a second component. The apparatus is formed of a first container made of a flexible material, having a communication mouth with an isolator and adapted to store the first component therein, a supporting case connected to the communication mouth, a second container having a mouth portion held in the case and a plug fitted in the mouth portion and adapted to store the second component, and a hollow, inflexible communication device capable of penetrating through the isolator and the plug. The communication device is accommodated in the first container and is attached to the communication mouth movably therein. The first and second containers can therefore be communicated with each other in a liquid-tight fashion by externally pressing the communication device toward the second container so that the first and second components can be mixed together without changing the positional relationship between the first and second containers.

Mixing apparatus

Disclosed herein is a filled and sealed, self-contained mixing container. The container has compartments which are isolated from each other. Plural substances which contain components susceptible to mutual reaction unless isolated from each other are contained in the respective compartments. In use, these compartments are communicated together so that the individual contents can be mixed within the container. A flow passage or passages, each of which has an isolator for the contents and is adapted to communicate the compartments with each other, and is formed by a side channel provided on an outer surface of a wall of the container. Mixing of the contents without exposure to the external atmosphere can be realized by irreversible destruction of the isolator upon use. The container is suited particularly for a closed therapy system.

Filled and sealed, self-contained mixing container

Surface of synthetic resin object is hydrophilicated by irradiation of ultraviolet rays.

Method for hydrophilication treatment of synthetic resin object, and

Disclosed is a medical fluid-filled plastic container which includes (a) a sealed inner envelope of plastic material filled with a medical fluid containing a component subject to deterioration by oxygen, (b) a deoxidizer, and (c) a sealed outer envelope of plastic material enclosing both the medical fluid-filled inner envelope and the deoxidizer, as well as several methods of making such a medical fluid-filled plastic container. This medical fluid-filled plastic container will prevent the medical fluid therein from being deteriorated even if it is subjected to steam sterilization or is stored for a long period of time.

Medical fluid-filled plastic container and methods of making same

A surface treatment method for improving the adhesiveness of a surface of a molded article made of a polyolefin resin with a printing ink, which entails irradiating the surface with an abundance of high-energy ultraviolet radiation from a high-output low-pressure mercury vapor lamp having an envelope made of synthetic quartz glass, and wherein the lamp has a wattage per unit lamp length of about 0.1-0.5 W/mm.

Surface treatment method

Disclosed is a medical fluid-filled plastic container which includes (a) a sealed inner envelope of plastic material filled with a medical fluid containing a component subject to deterioration by oxygen, (b) a deoxidizer, and (c) a sealed outer envelope of plastic material enclosing both the medical fluid-filled inner envelope and the deoxidizer, as well as several methods of making such a medical fluid-filled plastic container. This medical fluid-filled plastic container will prevent the medical fluid therein from being deteriorated even it it is subjected to steam sterilization or is stored for a long period of time.

A medical bag and method of manufacturing the bag from a thermoplastic resin by irradiating a ferromagnetic heating element which has been prepositioned between the mouth and receiving portions of the bag and which is caused to generate high frequence-induced heat. During subjection of the heating element to a high frequency magnetic field, the mouth portion and receiving portion of the bag melt about the element so that mouth portion, element and receiving portion are bonded together. This technique can also be suitably used for thermoplastic resins, for example, polyolefin resins, to which conventional high-frequency bonding cannot be applied.

Medical bag and method for preparing the same

A connector for therapeutic tubing comprising a tubular male connector member made of thermally resistant corrosionproof material, a tubular female connector member made of thermally resistant corrosionproof material and a locking mechanism coupled to the connector members and used for locking the union between the connector members. A medical solution bag device comprises a flexible bag, a flexible tube connected to the bag flexible, a further tube adapted to be connected to the flexible tube and the above mentioned connector for connecting the flexible tube to the further tube.

Connector for therapeutic tubing and medical solution bag device using

A connector for therapeutic tubing comprising a tubular male connector member made of thermally resistant corrosionproof material, a tubular female connector member made of thermally resistant corrosionproof material and a locking mechanism coupled to the connector members and used for locking the union between the connector members. A medical solution bag device comprises a flexible bag, a flexible tube connected to the flexible bag, a further tube adapted be connected to the flexible tube and the above mentioned connector for connecting the flexible tube to the further tube.

Medical permeating membranes in a zone through which a body fluid flows, said membranes having lateral surfaces in said zone, comprising permeable membranes of regenerated cellulose and a film of a fat-soluble vitamin and glycerin on said lateral surfaces of said membranes in said zone for flow of body fluid.

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Kawaguchi, Japan

Keinosuke Isono