Taiho Pharmaceutical Company Limited

Keiko Yamane

Yoshihiro Urade

Makoto Kitade

Kazuhiko Shigeno

Katsunao Tanaka

Hiroyoshi Yamanaka

Shinichi Aoki

Michinori Togawa

Yoshiki Tanaka

The present invention provides a piperidine compound represented by Formula (I) (wherein X, X, X, A, B and N are as defined in the Description); or a salt thereof.

Prostaglandin D synthase inhibitory piperidine compounds

This invention relates to a piperazine compound represented by Formula (I), wherein

Piperazine compound capable of inhibiting prostaglandin D synthase

This invention relates to a piperazine compound represented by Formula (I), 

The present invention provides a piperazine compound represented by Formula (I) or a salt thereof, wherein

Piperazine compound having a PGDS inhibitory effect

The present invention provides a benzimidazole compound represented by Formula (I) wherein Xis oxygen or carbonyl, and Ris a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents; excluding compounds represented by Formula (I) wherein at least one of the substituents is a phosphoric acid group or a phosphoric ester group; or a salt thereof. The benzimidazole compound or salt thereof has excellent prostaglandin synthase inhibitory activity, and is useful as an agent for preventing and/or treating diseases in which prostaglandin D2 or metabolites thereof participates, such as allergic and inflammatory diseases, and as inhibitor for the exacerbation of Alzheimer's disease or cerebral damage.

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Hanno, Japan

Keiko Yamane