Ajinomoto Co., Ltd.

Keiko Moki

Takashi Yamamoto

Seiji Niwa

Akira Takahara

Shinichi Fujita

Satoshi Iwayama

Tomoko Takeda

Yukitsugu Ono

Hajime Koganei

Seiji Ohno

Kayo Otani

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH&#x2550;CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V&#x2014;W represents C&#x2550;C, etc., n represents 0 to 3, Y1 represents O etc., B represents &#x2014;(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents &#x2014;CO&#x2014;, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, &#x2014;COR18a, &#x2014;COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

Diarylalkene derivatives and novel diarylalkane derivatives

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Kawasaki, Japan

Keiko Moki