Genox Research, Inc.

Keiko Matsui

Yuji Sugita

Nei Yoshida

Takeshi Nagasu

Kaoru Ogawa

Kenji Izuhara

Yukiho Imai

Tomoko Fujishima

Tadahiro Oshida

Noriko Ohtani

Masaya Obayashi

Shigemichi Gunji

Izumi Obayashi

Yuhei Hamasaki

SCCA1 and SCCA2 genes, whose expression were greatly changed in a plurality of cells by stimulating respiratory tract epithelial cells with IL-4 or IL-13, were obtained as allergy related genes. Furthermore, elevation of blood level of expression products of these genes accompanying bronchial asthmatic attack was elucidated. This invention provides a method of testing for bronchial asthmatic attack that uses as indicators, expression levels of these genes in biological samples.

Method of testing for bronchial asthma

T cells from multiple subjects who showed different cedar pollen specific IgE titers were prepared before and after cedar pollen dispersal, and differential display analysis was performed to screen for pollen antigen responsive genes. As a result, a novel gene was successfully isolated whose expression is significantly higher in subjects with high cedar pollen specific IgE titer. The inventors have found that it is possible to use this gene to test for an allergic disease and to screen for candidate compounds for therapeutic drugs for an allergic disease.

Pollen allergy-related gene 513

Growing community of inventors

Kawasaki, Japan

Keiko Matsui