C.i. Takiron Corporation

The University of Tokyo

Nissan Chemical Industries Limited

Keiko Kimura

Hideaki Takahashi

Hitoshi Furusho

Keitaro Yoshimoto

Akira Hori

Tomomi Hirota

Takayuki Ishimoto

A stretchable film including a stretchable film layer, a first skin layer disposed on the stretchable film layer on a first surface side, and a second skin layer disposed on the stretchable film layer on a second surface side, in which the stretchable film layer contains an elastomer, the first skin layer and the second skin layer contain a resin which does not have adhesiveness at 60&#xb0; C., and the thickness of each of the first skin layer and the second skin layer is 0.1 &#x3bc;m to 4 &#x3bc;m.

Stretchable film

[Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. [Solution] A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5'- or 3&#x2032;-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily.

Nucleic acid aptamers binding to vascular endothelial growth factor receptors

Porous stretchable film

Growing community of inventors

Tokyo, Japan

Keiko Kimura