Lion Corporation

Keikichi Sugiyama

Koji Takada

Ikuo Yamamoto

Kenkichi Oba

Keiji Kurusu

Akira Kiyomiya

Chikara Sato

Yoshiyuki Watanabe

Akira Fukushima

Makoto Egawa

Takuji Takeuchi

Methods and compositions containing cAMP salts in combination with inert carriers for preventing or restoring grayed hair to its natural color.

cAMP derivatives and use thereof for preventing or restoring grayed hair

A composition for preventing graying of the hair and restoring grayed hair to its natural color comprises an effective amount of one member selected from the group consisting of cAMP compounds such as 8-butylthio cAMP-Na or 8-methoxy cAMP-Na and water. The composition can prevent graying of the hair and restoring grayed hair to its natural color upon application to the scalp, the effective component is very stable even in the form of compositions containing water and the composition does not cause quality deteriorations such as giving out of bad smell.

Composition for preventing graying of the hair and restoring grayed hair

Methods and compositions for restoring grayed hair to its natural color comprising at least one compound of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hydrogen atom, an acyl group having 5 to 15 carbon atoms derived from a monocarboxylic acid having 5 to 15 carbon atoms or an acyl group having 2 to 15 carbon atoms derived from a dicarboxylic acid having 2 to 15 carbon atoms or an alkyl group having 1 to 2 carbon atoms; X.sub.1 and X.sub.2, respectively, represent a hydrogen atom, a halogen, or a mercapto group; with the proviso that when R.sub.1, R.sub.2 and R.sub.3 and X.sub.1 are hydrogen atoms at the same time, X.sub.2 is not a halogen atom or a mercapto group, and M.sub.1 represents a hydrogen atom, an alkali metal or tris(hydroxymethyl)aminomethane.

Composition for application to hair

Composition for preventing graying of the hair

A melanocyte-stimulating hormone inhibitor has an amino acid sequence represented by the following formula [I], [II] or [III] in the molecule:

Melanocyte-stimulating hormone inhibitor and external preparation

A composition for application to hair or scalp comprises (A) at least one compound selected from the group consisting of (i) forskolin and derivatives thereof and (ii) peptides having a basic skeletal structure represented by the following general formula (I):

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Kanagawa, Japan

Keikichi Sugiyama