Daiichi Sankyo Company, Limited

Keijiro Kobayashi

Hideaki Watanabe

Hitoshi Ohki

Yoshihiro Shibata

Masahiro Ota

Hisaki Kajino

Yuichi Tominaga

Katsuhiro Kobayashi

Takeshi Jimbo

Shinji Matuura

Daisuke Fukatsu

Akitake Yamaguchi

Kosuke Takeuchi

Tomoyuki Nagai

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R, R, R, R, R, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.

Pyridone derivatives

To provide a hydrochloride of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90 and a crystal thereof. The present invention provides a hydrochloride of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a crystal thereof, a medicament comprising the same, an anticancer agent comprising the same, and the like.

Crystal of tricyclic pyrazolopyrimidine derivative

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Kanagawa, Japan

Keijiro Kobayashi