Kyowa Hakko Kirin Co., Limited

Keiji Uehara

Keisuke Yamamoto

Michihiko Suzuki

Tomohiro Tamura

Takeshi Kuboyama

Kimihisa Ueno

Arata Yanagisawa

The invention provides a method of activating PPAR &#x3b3; and a method of treating or preventing a disease associated with PPAR &#x3b3; by administering a tricyclic compound having a PPAR &#x3b3; agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R-Rare the same or different and each represents hydrogen or the like, V represents a single bond or the like, Rand Rare the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like: 

Tricyclic compound

Provided is a tricyclic compound having a PPAR &#x3b3; agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R-Rare the same or different and each represents hydrogen or the like, V represents a single bond or the like, Rand Rare the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like: 

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Machida, Japan

Keiji Uehara