Canon Kabushiki Kaisha

Msd K.k.

Banyu Pharmaceutical Co. Ltd

Keiji Takahashi

Satoshi Sunami

Toshihiro Sakamoto

Kenji Niiyama

Hidetomo Furuyama

Makoto Bamba

Fuyuki Yamamoto

Takashi Yoshizumi

Yasuhiro Goto

Teruyuki Nishimura

Jun-ichi Eiki

Takeshi Sagara

Hiroshi Hirai

Noriaki Hashimoto

Sachie Otsuki

Toshihide Nishibata

Hirofumi Hirano

Tetsuji Kurata

Toru Shinano

Yoshio Ogino

Tomoharu Iino

Hiroshi Nakashima

Hiroshi Nakai

Yoshitaka Okamura

Katsumi Munenaka

Fumiko Sakai

Chisato Nakama

Jun-Ichi Eiki

The invention relates to compounds of a general formula (I): wherein Aris an optionally-substituted aryl or heteroaromatic group; Ris an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom or a lower alkyl group; Ris a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of &#x2014;N(R)R; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Dihydropyrazolopyrimidinone derivatives

The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Aris an optionally substituted aryl or heteroaryl group; Ris a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; Ris an optionally substituted aryl, aralkyl, or heteroaryl group; and Ris a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy. 

Dihydropyrazolopyrimidinone derivative

The invention relates to a compound of a general formula (I): wherein Aand Aeach mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; Rmeans a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; Rmeans an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of &#x2550;NH or &#x2550;O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

Bicycloaniline derivative

The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a): Rmeans a &#x2014;(C&#x2550;O)O(C1-C6)alkyl group, a &#x2014;(C&#x2550;O)O(C2-C6)alkenyl group, a &#x2014;(C&#x2550;O)O(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; Rand Reach mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a &#x2014;(C&#x2550;O)O(C1-C6)alkyl group or a group of &#x2014;(C&#x2550;O)N(R)R; Rmeans a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments. 

Pyrimidopyrimidoindazole derivative

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein Rand Rrepresent a hydrogen, etc.; Rrepresents a hydrogen atom, a halogen atom, etc.; Reach independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); Rand Reach represent a hydrogen atom, a lower alkyl group, etc.; X, X, Xand Xeach independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group &#x3b2;; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of Xto Xare carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

Aryloxy-substituted benzimidazole derivatives

Substituted pyrazolo[3,4-d]pyrimidinone derivatives

Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, Rrepresents an aryl or the like; Rrepresents an aryl or the like; Rrepresents a formyl or the like, Rrepresents a Calkyl or the like; Rrepresents a hydrogen atom or the like; Zrepresents &#x2014;O&#x2014; or the like; Zrepresents &#x2014;O&#x2014; or the like; Y-Yrespectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.

2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions

Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein Xrepresents oxygen, etc., Xrepresents oxygen, etc., Rrepresents a group on Ring A such as alkylsulfonyl, etc., Rrepresents C3-7 cyclic alkyl optionally substituted with a halogen, etc., Rrepresents a substituent on Ring B such as lower alkyl, etc., formula (II):[Chemical Formula 1] represents 6- to 10-membered aryl, etc., and formula (III):[Formula 1] represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by Rabove, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C&#x2550;N bond with the nitrogen atom of the ring],as well as their pharmaceutically acceptable salts.

Heteroarylcarbamoylbenzene derivatives

Compounds represented by formula (I): as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes and related conditions. Compositions and methods of treatment are also included.

Heteroarylcarbamoylbenzene derivative

Down-sizing of a pump for sucking two types of different fluids is realized. The pump is provided with a cylinder pump having a cylinder main body having a reciprocally movable piston, a first cylinder chamber partitioned at one side of the piston for being introduced with a first fluid, and a second cylinder chamber partitioned at the other side of the piston for being introduced with a second fluid, and piston driving means for reciprocally moving the piston of the cylinder pump.

Cylinder pump, an ink jet printing system using the cylinder pump and a photograph assembly having the printing system

An ink supply recovery system comprises a pack body including a main tank and a waste ink receptacle. The pack body is detachably mounted on a printer body. The printer body includes a sub-tank mounted on a carriage, a cap for capping ink ejection openings of a printing head, and a cylinder pump. The pump has a reciprocally movable piston, a cylinder body having air and ink suction chambers, defined on opposite sides of the piston, respectively connectable with a negative pressure introducing portion of the sub-tank, the cap via an input port and the waste ink receptacle via an output port, and a port switching mechanism which switches the input and output ports open and close associating with movement of the piston. Movement of the piston of the cylinder pump is controlled at a predetermined timing.

Ink supply recovery system, ink-jet printing apparatus and image pick-up device having recording mechanism

A sheet member feeding device comprises a first gear transmitting a driving force to a feeding roller for intermittently feeding a sheet member per a predetermined feeding amount, a second gear having a first mark and a second mark representative of a maximum eccentric position and a minimum eccentric position along a radial direction relative to a predetermined concentric circle in a tooth space, in opposition to each other and directly or indirectly transmitting a driving force to the first gear, a third gear directly or indirectly transmitting driving force from driving means to the second gear, detecting means for detecting the first mark and the second mark in the second gear and transmitting a detection output, and a control portion operating the driving means for performing operation for rotating the second gear through 180&deg; between the first mark and the second mark with respect to feeding for a feeding amount of the sheet member for one time, on the basis of the detection output from the detecting means.

Sheet member feeding device, recording apparatus employing the same and image pick-up apparatus with recording mechanism

The present invention provides an ink jet image recording apparatus adapted for use in mobile printing, and a media cartridge for containing a sheet to be recorded by such apparatus. The media cartridge is detachably mountable on an image recording apparatus for forming an image on a sheet and includes a frame body which includes sheets for recording an image by the image recording apparatus, an ink containing member for containing ink to be supplied to an image recording unit of the image recording apparatus and to be discharged on the sheets, a pick-up unit for feeding the sheets one by one from the frame body, and an ink absorbent member for absorbing the ink not used for recording in the image recording apparatus in a state that the frame body is mounted thereon.

Growing community of inventors

Tsukuba, Japan

Keiji Takahashi