3-D Matrix, Ltd.

Nec Corporation

Keiji Nagano

Eun Seok Gil

Yuya Hasegawa

Toshiro Kiyofuji

Satoru Kobayashi

Karl Patrick Gilbert

Marc Rioult

Hideo Kikuchi

Marika G Rioult

Yutaka Akimoto

Karl Partick Gilbert

Marika Gaelle Rioult

[Problem to be Solved] It is intended to provide a composition for hemostasis which can be uniformly applied to a bleeding site and exerts a high hemostatic effect. [Solution] The present invention provides a composition to be applied as a spray to a subject, the spray being used for hemostasis, and the composition comprising a self-assembling peptide, wherein the self-assembling peptide self-assembles and thereby gels when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration at which the composition has an improved hemostatic ability as compared with that when directly applied.

Hemostatic composition and hemostatic method using hemostatic composition

Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.

Self-assembling peptides comprising non-Ionic polar amino acids

[Problem] To provide a composition for hemostasis that can be applied uniformly to a bleeding site and exerts a high hemostatic effect. [Solution] Provided is a composition to be applied to the subject as a spray, wherein the composition is characterized in that the spray is for hemostasis, and the composition includes a self-assembling peptide, the self-assembling peptide gelling due to self-assembly when the composition is applied to the bleeding site of the subject, and the self-assembling peptide being included in the composition in a concentration having an improved hemostatic capacity in comparison to direct application.

Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.

Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion

Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising or consisting essentially of serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.

Self-assembling peptides comprising non-ionic polar amino acids

A layout compaction method adapted to be embodied in computer program product and adapted for compacting a circuit layout having a plurality of layers on which moving objects form layer patterns, wherein the moving objects comprising components and wires. The method assumes a graph problem under condition which prevent the compacted result from violation of the design rule, and then, solves the graph problem to determine a moving order, a moving direction, and a moving distance of each component for moving the components to thereby perform the compacting the circuit layout. After that, the method moves each component according to the moving order, the moving direction and the moving distance to obtain a compacted circuit layout.

COMPACTING METHOD OF CIRCUIT LAYOUT BY MOVING COMPONENTS USING MARGINS AND BUNDLE WIDTHS IN COMPLIANCE WITH THE DESIGN RULE, A DEVICE USING THE METHOD AND A COMPUTER PRODUCT ENABLING PROCESSOR TO PERFORM THE METHOD

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Tokyo, Japan

Keiji Nagano