Shionogi Company Limited

Keiichiro Hirai

Tomoyuki Ogawa

Hiroyuki Kai

Noriyuki Kurose

Satoru Tanaka

Yasuhiko Fujii

Yuki Ogata

A compound represented by Formula (I): wherein or the like,Yis O or the like; Zis C(R) or N; Zis C(R) or the like; Zis C(R) or the like; R, Rand Rare each independently a hydrogen atom or the like; Ris substituted or unsubstituted aromatic carbocyclyl or the like; R, R, Rand Rare each independently a hydrogen atom or the like; X is N(R) or the like; Ris a hydrogen atom or the like; Ris or the like,Ring B is a 6-membered aromatic carbocycle or the like; Rand Rare each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3,or a pharmaceutically acceptable salt thereof.

6-membered heterocyclic derivatives and pharmaceutical composition comprising the same

A compound represented by Formula (I): wherein or the likeYis O or the like; Zis C(R) or N; Zis C(R) or the like; Zis C(R) or the like; R, Rand Rare each independently a hydrogen atom or the like; Ris substituted or unsubstituted aromatic carbocyclyl or the like; R, R, Rand Rare each independently a hydrogen atom or the like; X is N(R) or the like; Ris a hydrogen atom or the like; Ris or the likeRing B is a 6-membered aromatic carbocycle or the like; Rand Rare each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3,or a pharmaceutically acceptable salt thereof.

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Osaka, Japan

Keiichiro Hirai