Kao Corporation

Keiichi Yoshikawa

Naoko Saito

Tomohiro Nakagawa

Masanori Matsuura

A method for searching for a substance suppressing a target odor through cross-adaptation is provided. A method for selecting a substance inducing cross-adaptation of a target odor includes: searching olfactory receptor polypeptides to identify an olfactory receptor polypeptide responding to a causative substance of the target odor; adding a test substance, which is different from the causative substance of the target odor, to the identified olfactory receptor polypeptide to measure response thereof; and selecting the test substance which activates the response of the olfactory receptor polypeptide as the substance inducing the cross-adaptation of the target odor.

Method for selecting odor-controlling substance

Provided an agent for suppressing an odor of a polysulfide compound. This agent for suppressing an odor of a polysulfide compound comprises, as an active ingredient, at least one selected from the group consisting, butyl 2-methylbutanoate, &#x3b1;-terpinene, dipentene, cis-4-heptenal, 1,4-cineol, trimethylhexyl aldehyde, and (+)-limonene oxide, wherein the polysulfide compound is represented by the following formula (I): R&#x2014;[S]&#x2014;R(I) (in the formula, Rand Rare the same or different, and each denote a linear-chain or branched-chain alkyl or alkenyl group having 1 to 6 carbon atoms, and n denotes an integer of 2 to 5).

Agent for suppressing odors of polysulfide compounds

The present invention identifies substances which suppress odors of sulfide compounds. Provided is a method for evaluating and/or selecting an agent for suppressing odors of sulfide compounds, the method comprising: adding a test substance and a sulfide compound to at least one olfactory receptor polypeptide selected from the group consisting of OR4S2 and polypeptides having an amino acid sequence identity of at least 80% to OR4S2; and measuring the response of the olfactory receptor polypeptide to the sulfide compound.

Method for evaluating and selecting agent for suppressing odors of sulfide compounds

Provided are a novel compound useful for adjusting sweetness or saltiness or inhibiting ENaC, and use thereof. An octenyl sulfate ester of the following Formula (1) or a salt thereof, wherein the wavy line represents any one of cis- or trans-configuration. 

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Saitama, Japan

Keiichi Yoshikawa