Kyowa Hakko Kogyo Co., Ltd.

Abbott Laboratories Corporation

Kyowa Hakko Kogyo

Keiichi Takahashi

Hirofumi Nakano

Kunikatsu Shirahata

Fusao Tomita

Makoto Morimoto

Tadashi Ashizawa

Toru Yasuzawa

Yutaka Saito

Hiromitsu Saito

Isao Kawamoto

Isami Takahashi

Seigo Takasawa

Tomoyasu Sato

Kozo Asano

Shigeo Katsumata

Nobuo Nakamura

Shuji Okubo

Seiji Sato

Hiroshi Sano

Yoshinori Yamashita

Chikara Murakata

Masaji Kasai

Shiro Akinaga

Katsuhiko Ando

Tadashi Hirata

Takashi Nara

Eiji Kobayashi

Ryo Okachi

Yuzuru Matsuda

Masami Okabe

Takao Iida

Shinzo Ishii

Shigeru Kobayashi

Akira Mihara

Tatsuhiro Ogawa

Masahiro Sugimoto

Yuko Arai

Kazuhisa Fujimoto

Toshimitsu Takiguchi

Michio Ichimura

Yuzura Matsuda

Kenichi Muroi

Hiroe Ohno

Disclosed is a process for producing a staurosporine derivative represented by Formula (I): Q is defined as in specification: ##STR1## The staurosporine derivative (I-1) possesses selective protein kinase C-inhibitory and cell growth-inhibiting activities, and platelet-increasing activity.

Process for producing staurosporine derivatives

Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

DC-89 compounds and process for their preparation

A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.

Novel substance DC 113 and production thereof

Disclosed is novel compound UCT-1003 represented by the following formula: ##STR1## and having anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces.

Novel substance UCT-1003 and process for producing the same

Antibiotic compounds DC-92B and DC-92D

A compound represented by the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is a hydroxymethyl group and Y is a cyano group, and when R is a lower alkyl group, X and Y may combine to form --CH.sub.2 --O--, and salts thereof, process for preparing the same, and an anti-tumor composition containing the same, which is improved in stability in comparison with a starting compound DC-52.

DX-52-1 compounds and process for preparing the same

New antibiotic compounds, Fortimicin factors KG.sub.1, KG.sub.2 and KG.sub.3 are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.

Fortimicin factor KG.sub.3

Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities. Some of these compounds are produced by incubation of a microorganism.

Phenazine carboxylic acid derivatives and a process for production

The antibacterial compound DC-38-V is produced by culturing a microorganism belonging to the genus Streptomyces.

Compound DC-38-V and process for production thereof

Novel compound DC-38-V and process for production thereof

Fortimicin factors KG.sub.1, KG.sub.2 and KG.sub.3 and processes for

New antibiotic compounds, Fortimicin factors KF and KG are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.

Fortimicin factors KF and KG and process for production thereof

Growing community of inventors

Machida, Japan

Keiichi Takahashi