Eisai R&d Management Co., Ltd.

Keiichi Sorimachi

Toshiaki Tanaka

Yu Yoshida

Yuji Kazuta

Taro Terauchi

George Moniz

Yoichi Kita

Yoshimitsu Naoe

Farid Benayoud

Annie Zhu Wilcoxen

Ayumi Takemura

Toru Watanabe

Takashi Kosasa

Makoto Kotake

Takashi Doko

Huiming Zhang

Jaemoon Lee

Takafumi Motoki

Takahisa Hanada

Carsten T Beuckmann

Hiroyuki Higashiyama

Toshiyuki Ohfusa

Yukio Ishikawa

Minako Saito

Tetsuyuki Teramoto

Taro Asaba

George Anthony Moniz

Provided are compounds represented by the following formulas (I), (II), (III) and (IV) having orexin type 2 receptor-activating activity, or their pharmaceutically acceptable salts. 

Substituted piperidine compounds and their use

The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

Novel indansulfamide derivatives or a pharmaceutically acceptable salt thereof such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (+)-N-(2,2,4,6,7-pentafluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, have an action of improving Seizure Severity Index (Score) in mice kindling model. Thus the compounds or the salt thereof are expected as a drug for treating epilepsy.

Indanesulfamide derivatives

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents &#x2014;CH&#x2014; or a nitrogen atom, Rand Reach independently represent a Calkyl group and the like, Rrepresents a hydrogen atom and the like, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, a Calkyl group and the like, R, Rand Reach independently represent a hydrogen atom, a halogen atom and the like, and Rrepresents a hydrogen atom and the like.

Cyclopropane compound

Growing community of inventors

Tsukuba, Japan

Keiichi Sorimachi