Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Keiichi Motosawa

Yuichi Takahashi

Takashi Sawada

Hiroshi Ishida

Takayuki Furuta

Yusuke Miura

Noriaki Uesaka

Ryuichiro Nakai

Masamori Sugawara

Tomohiro Danjo

Maki Ichioka

Ryoko Okada

A Wnt signaling inhibitor which comprises, as an active ingredient, a fused-ring heterocyclic compound represented by the following formula (IA) or a pharmaceutically acceptable salt thereof, and the like are provided: (wherein, nrepresents 0 or 1; nand nmay be the same or different, and each represents 1 or 2; Rrepresents optionally substituted aryl or the like; Rrepresents a hydrogen atom or the like; Rrepresents an optionally substituted aromatic heterocyclic group or the like; X, X, Xand Xeach represent CH or the like; Yrepresents CHor the like; Yrepresents N or the like; and Lrepresents CHor the like).

Wnt signaling inhibitor

A ring-fused heterocyclic derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof having a T-type calcium channel regulatory effect and useful as a pruritus therapeutic and/or preventive agent, and the like are provided. In the general formula (I), Rrepresents optionally substituted lower alkyl, and the like; Rrepresents an optionally substituted cycloalkyl, and the like; Q represents a hydrogen atom, and the like; Rrepresents &#x2014;C(&#x2550;O)NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, and the like), and the like; Lrepresents &#x2014;CRR&#x2014; (wherein Rand Rmay be the same or different, and each represents a hydrogen atom, and the like), and the like; and Wand Wmay be the same or different, and each represents C&#x2014;R(wherein Rrepresents a hydrogen atom, and the like), and the like. 

Ring-fused heterocyclic derivative

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Sunto-gun, Japan

Keiichi Motosawa