Nippon Shinyaku Company, Ltd.

Keiichi Kuwano

Tetsuo Asaki

Taisuke Hamamoto

The main object of the present invention is to provide a novel agent for the treatment of spinal canal stenosis. The present invention relates to an agent for the treatment of spinal canal stenosis containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient;  In the formula (1),

Therapeutic agent for spinal canal stenosis

The present invention provides a compound which is useful as a PGIreceptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (Rand Rare the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR, O, S, or ethylene, Rrepresents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH, Rand Rare the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.

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Osaka, Japan

Keiichi Kuwano