Zenyaku Kogyo Kabushiki Kaisha

Juntendo University School of Medicine

Pharmacia & Upjohn Company

Denka Seiken Co., Ltd.

Juntendo Educational Foundation

Kainos Laboratories, Inc.

Microbial Chemistry Research Foundation

Keiichi Hiramatsu

Hiroaki Yamazaki

Seiichiro Kawashima

Hideaki Hanaki

Kanenari Ohishi

Tadashi Baba

Yasuo Nakatomi

Hideki Sato

Akira Awaya

Yoshio Tsuchida

Jumpei Enami

Donald Herman Batts

Hiroyoshi Ohsawa

Hidenori Harada

Teruyo Ito

Hiroie Ohno

Tsukasa Hayashi

[Problem] The present invention addresses the problem of providing an anti-antibody having preventive or therapeutic effects on staphylococcal infections. [Solution] Provided is an anti-antibody having preventive or therapeutic effects on staphylococcal infections and a method for manufacturing said antibody, as well as a composition, a product, and a drug containing said antibody. The antibody is obtained by using deacetylatedfor immunization.

[object Object]

According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused bycontaining PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

Toxin detection method

A cephem compound or pharmaceutically acceptable salt thereof represented by the formula I:wherein Rand Rmay be the same or different and each represent hydrogen atom, nitro or cyano; Rrepresents C-Calkyl which may be substituted with carboxyl; Rrepresents hydrogen atom or amino; X represents &#x2014;S&#x2014; or &#x2014;SO&#x2014;, there being no case where both of Rand Rare simultaneously hydrogen atom.

Cephem compounds and ESBL-detecting reagents containing the same

A composition having antibacterial activity is disclosed. More particularly, a mixture of an oxazolidinone compound, sulbactam, and ampicillin active agents, demonstrating activity against resistant strains of bacteria is disclosed. Methods for using an oxazolidinone compound, sulbactam, and ampicillin to treat a bacterial infection are also described.

Compositions and methods for treating bacterial infections

Cephem compounds

Method of identifying methicillin-resistant Staphylococcus aureus or

Growing community of inventors

Tokyo, Japan

Keiichi Hiramatsu