Jcr Pharmaceuticals Co., Ltd.

Keihide Koh

Yoshikazu Komurasaki

Satoshi Nishimuro

Hiromichi Ishikawa

Hideyuki Kobayashi

Takashi Hirose

Chihiro Shindoh

Mitsugu Fujita

The present invention provides a process for purifying Tamm-Horsfall glycoprotein (THG) and uromodulin, which permits THG and uromodulin to be purified with enhanced efficiency by the simplified procedure, as well as a method for making the discrimination between both of them.

Process for purifying Tamm-Horsfall glycoprotein or uromodulin their

According to the present invention, there are provided suppressory agents against hypercoagulation which comprise as an effective ingredient protein C inhibitor with a molecular weight of 54 to 57 kDa (DS-PAGE) being capable of suppressing function of the blood coagulation system.

Suppressory agents against hypercoagulation

The present invention, using a readily available sulfated chitin as an adsorbent, can permit platelet factor-4 to be recovered through specific adsorption from a solution containing the same factor, in by far increased yields as compared with the conventional process utilizing a heparin-immobilized affinity column, and provides the process for isolating, through purification platelet factor-4 which is suited for a commercial-scale, mass production process, wherein there can be offered the advantages of utilization of more readily available sulfated chitin, simplified procedure and improved production yields for the objective substance.

Process for obtaining platelet factor-4

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Kobe, Japan

Keihide Koh