Adjucor Gmbh

Ebenbuild Gmbh

Kei Wieland Müller

Andreas Maier

Stephen Manuel Wildhirt

Maximilian Josef Grill

Jakob Richter

Karl-Robert Klaus Wichmann

David Rudlstorfer

Bjorn Hofmann

Jonas Biehler

Björn Hofmann

The invention relates to systems and methods for assessing the efficacy of an aerosol for pulmonary drug delivery as well as to an inhaler device, an orally inhaled drug product and a drug/device combination product. An aerosol can be generated by an inhaler device and comprises aerosol particles containing an orally inhaled drug product. The method comprises the steps of providing a computational lung model and a computational particle transport and deposition model, computing a spatial particle deposition distribution of discrete particles based on a determined aerosol value of an aerosol parameter, computing an efficacy value of an efficacy parameter based on the spatial particle deposition distribution and using the efficacy value for automatically assessing the efficacy for pulmonary drug delivery of the aerosol.

Method for assessing the efficacy of an aerosol for pulmonary drug delivery as well as inhaler device, orally inhaled and/or nasal drug product and drug/device combination product

A device for administration of substances onto an epicardial surface of a heart includes a frame structure for at least partially encircling a circumference of the heart which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may be coupled to a heart-shaped sleeve. A substance carrier for accommodating the substances to be administered may be coupled to the device.

Implantable device for the locationally accurate delivery and administration of substances into the pericardium or onto the surface of the heart

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Munich, Germany

Kei Wieland Müller