Japan Science and Technology Agency

Japan Science and Technology Corporation

Kei Manabe

Shu Kobayashi

The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst. Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4) with scandium triflate and the like.

Method for producing optically active hydroxymethylated compounds

A silicon enolate represented by the following formula (Formula 1) 

Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore

A method for aldol reaction in water, which comprises: reacting an aldehyde with a silyl enol ether in an aqueous medium in the presence of a boronic acid represented by the following general formula (1):RRBOH&#x2003;&#x2003;(1)(wherein Rand Rare the same or different hydrocarbon groups that may contain a substituent), a surfactant, and a Br&#xf8;nsted acid is provided. This method for aldol reaction in water uses a catalytic amount of the boron source to give products in high yield and selectivity.

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Tokyo, Japan

Kei Manabe