Roche Palo Alto LLC

Syntex (u.s.a.) Inc.

F. Hoffmann-La Roche Ag

Keena Lynn Green

Charles Alois Dvorak

Gary R Lee

Ralph New Harris, Iii

David Bruce Repke

Lawrence Emerson Fisher

Hans Maag

Russell Stephen Stabler

Anthony Prince

Eric Roy Humphreys

Patrick Finbar McGarry

Anton Constantinescu

Anton Constantinescue

A method for preparing a compound of formula k  

Process for synthesis of phenoxy diaminopyrimidine derivatives

A method for preparing a compound of formula k or a salt or solvate thereof, or a salt or solvate thereof,with ammonia, to form the compound of formula k.

A method for preparing a compound of formula k or a salt or solvate thereof, or a salt or solvate thereof,

A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R, Rand Rare as defined herein.

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

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Newark, CA, United States of America

Keena Lynn Green