Diametrics Medical Limited

International Technidyne Corporation

Ppg Industries, Inc.

Other

Kee Van Sin

Carter R Anderson

Matthew J Leader

Marshall L Sherman

James D Kurkowski

Scott Everett Blomberg

Jeffrey A Graves

David T Giddings

Robbi T Thompson

Douglas R Savage

Ronald E Betts

Richard J Koerner

Dennis D Leatherman

Martin G Hieb

Walter L Sembrowich

Kellie Erbisch

Jon J Crumm

Frank Solomon

Brian Anthony Ott

James A Russell

An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.

Analytical test cartridge; and, methods

A system for operating at least first and second amperometric sensors includes a cartridge and a control device. The cartridge includes a first amperometric sensor and a second amperometric sensor. The first amperometric sensor is in fluid flow communication with a liquid sample inlet and includes a first electrode. The second amperometric sensor is in fluid flow communication with a liquid sample and includes a second electrode. The control device sets the first and second electrodes to about the same potential such that the first and second amperometric sensors can be operated simultaneously.

Apparatus and method for analytical determinations using amperometric techniques

A portable device that includes a plurality of test modules for analyzing preselected concentrations of various body fluids of a patient. The portable diagnostic device interfaces and utilizes disposable cartridges and reagent diagnostic test strips and other fluid sample diagnostic devices to determine the amounts of preselected parameters in a patient's blood through either electrochemical, electrical, optical, or mechanical analysis. The disposable fluid sample diagnostic devices may include sample chambers with inlet ports, electrical, physical, or chemical sensors, in situ calibration media, a plurality of electrical interface terminals, and temperature control elements. An electrical interface interconnects the various test modules with one or more corresponding integrated circuits which in turn are electrically coupled to a common interactive display, printer, power supply, and communication ports.

Portable immediate response medical analyzer having multiple testing modules

An apparatus and method for measuring conductance are provided. The method and apparatus are particularly well adapted for use with a removable or replaceable cartridge in a blood analysis system. The apparatus generally involves providing a system having a first, unfiltered, conductance measurement cell and a second, filtered, conductance measurement cell. The preferred method involves relating values measured in the two cells for a whole blood sample and for a known calibrant together, to obtain a value, for example hematocrit, for the unknown whole blood sample.

Apparatus and method for analytical determinations

The present invention provides a method for determining the coagulation propensity of blood wherein a condition in a portion of a blood sample is assessed and related to the onset of coagulation. Apparatus for performing the method is encompassed by the invention.

Method for measurement of whole blood coagulation parameters

Portable immediate response medical analyzer having multiple testing

A portable clinical system for providing a rapid electrochemical analysis of biological sera of interest at the point-of-care using a portable analyzer unit and a multi-sensor electrochemical plug-in cartridge analyzing system is disclosed which features a plug-in module including a reusable sensor cartridge having an inlet port for receiving a sample, an outlet drain port and array of self-calibrating electrochemical sensors, a plurality of electrical interfaced terminals for interfacing with the portable analyzer unit. An integral flushing system is provided for cleaning and allowing recalibration of the sensor between sample analyses. Connection devices on the analyzer unit and plug-in multi-use test module are provided for removably attaching the module to the analyzer unit. The connection devices are configured to receive a single-use sensor cartridge interchangeably and without modification with said plug-in multi-use test module.

Interchangeable multiple test system for portable analyzer

A sensor apparatus is provided that is the sensor with or without accompanying sample collector means and calibration means in a hermetically sealed layer that contains at least one preconditioning fluid. The preconditioning fluid is an activating fluid when the sensor is in an unsealed housing and can be either or both the activating fluid or a controlled-content fluid when the sensor is in a sealed housing. The sealed housing is one that has the preconditioning fluid sealed in fluid contact with the one or more sensors on a sensor element. The sensor element also has an electrical circuit means in electrical contact with the one or more sensor on a nonconducting substrate. When both preconditioning fluids are present the activating fluid is in fluid contact with the one or more sensors in the sealed housing and the known-content fluid is present in the atmosphere in the hermetically sealed layer outside the sealed housing. The sealed layer is impervious to gas and moisture and is a diffusion-tight boundary or barrier.

Electrochemical sensor storage device

A reference electrode system for a disposable test cell which provides both a reference electrical potential and a liquid junction between the reference medium and an analytic or sample medium to which a sample is introduced to be tested includes a substrate carrying and supporting a thin metallic electrode layer, an hydrophilic medium overlays the electrodes, a portion connecting the metallic layer and the sample conducting medium to provide an electrical connection and free diffusion liquid junction with the sample medium, a liquid impermeable dielectric barrier layer sealing all but a selected, relatively minor portion of the hydrophilic medium exposed to contact the analytic medium. Electrolyte salts introduced into the free diffusion channel control both the reference electrode potential and the junction potential.

Reference electrode

Portable medical analyzer

A gaseous oxygen electrochemical sensing system sustains inter-electrode ionic conductivity by the use of a combination of an hydrophilic coating layer on a gas-permeable barrier or separation membrane to supply sufficient moisture to the electrolyte of an electrode system to activate the sensor and sustain proper operation.

Self-activating chemical sensor system

An improved electronic wiring board having a thermistor and at least one blood gas sensor supported, in close relation, one to the other, on one side of the board and a heater supported on the other side of the board to provide heat in response to temperature sensed by the thermistor, to at least the region where the thermistor and the blood gas sensor are positioned on the board to control the temperature of the region of the board within a narrow distribution of temperatures.

Electronic wiring substrate

A plastic covered nonconducting substrate with an electrical circuit means is secured to the extent to withstand the presence of liquids in contact with the substrate. The covered substrate can have the substrate with one or more fluid preconditionable electrical components, a housing secured to the substrate to maintain contact of the preconditioning fluid with the electrical component like a sensor, and moisture impervious seals to cover openings in the housing for the disposition of the preconditioning fluid in the housing for contact with the electrical component on the substrate. The housing can have one or more parts and have one or more channels for containing the preconditioning fluid. The electrical component can be an improved electronic wiring board having a thermistor and at least one blood gas sensor supported, in close relation, one to the other, on one side of the board and a heater supported on the other side of the board to provide heat in response to temperature sensed by the thermistor, to at least the region where the thermistor and the blood gas sensor are positioned on the board to control the temperature of the region of the board within a narrow distribution of temperatures.

Integrated circuit hydrated sensor apparatus

The sensor apparatus of the present invention includes on a nonconducting substrate electrically conductive pathways leading to at least two analyte electrodes and one reference electrode. The analyte electrodes each have sensitivities for both analytes but each has a membrane and/or electrolyte that favors the conversion of ionic potential to electronic potential for a different analyte. The apparatus has an fluid circuit means for liquid contact between the electrodes so that electric signals can be sent by electric circuitry to an analyzing means. The analyzing means determines the values of the analytes from the following simultaneous relationships: ##EQU1## where: delta mV=change in millivolts

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Lino Lakes, MN, United States of America

Kee Van Sin