Juno Therapeutics Gmbh

Kedar Himanshu Dave

Christopher Glen Ramsborg

Ryan P Larson

Nathan K Yee

Claire L Sutherland

Jeff D Smith

Mark J Gilbert

He Li

Pascal Beauchesne

Clinton Weber

Brian Christin

Tom Kowski

Kathryn Lindsay Pollock

Valerie Odegard

Rachel K Yost

Andrew W Walker

Mary Mallaney

Ronald James Hause, Jr

Todd Devries

Nikolaus Sebastian Trede

Michael Gerard Covington

Richard James Getto, Jr

James Boyd Whitmore

Travis Beckett

Samuel Charles Blackman

Nathaniel Chartrand

Nathaniel Lambert

Mel Davis-pickett

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Determining toxicity risk in CAR T-cell therapy

Provided are methods, compositions and articles of manufacture for use in cell therapy involving the administration of one or more doses of a therapeutic T cell composition, and methods, compositions and articles of manufacture for use in the same. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the embodiments of the present disclosure, including the dose of cells or units of cells administered and/or the phenotype of administered cells, provide various advantages, such as consistent dosing, lower risk of toxicity and/or increased response in subjects administered the T cell compositions.

Phenotypic markers for cell therapy and related methods

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Seattle, WA, United States of America

Kedar Himanshu Dave