Lonza Sales Ag

Codiak Biosciences, Inc.

Other

Ke Xu

John D Kulman

Douglas E Williams

Nikki Ross

Damian J Houde

Kevin P Dooley

Rane A Harrison

Sonya Haupt

Russell E McConnell

Sriram Sathyanarayanan

Nuruddeen D Lewis

Shelly Martin

Yu Zhou

Leonid A Gaydukov

Christine Mccoy

Timothy J Soos

Raymond J Moniz

Russell E Mcconnell

Madeleine Youniss

Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.

Exosomes for immuno-oncology and anti-inflammatory therapy

The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

Preparation of therapeutic exosomes using membrane proteins

The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.

Extracellular vesicles for vaccine delivery

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Sudbury, MA, United States of America

Ke Xu