Hutchison Medipharma Enterprises Limited

Jiangsu Yahong Meditech Co., Ltd.

Ke Pan

Tao Wang

Yu Cai

Liang Wu

Xiaoqiang Yan

Weihan Zhang

Zhiming Ma

Jeff Duan

Yijun Deng

Jianrong Hong

Provided are a nitroxoline prodrug and a use thereof. Specifically, provided are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, a composition containing the compound, and a use thereof in the preparation of anti-infective and antitumor drugs, and definitions of groups in formula (I) are as stated in the specification. The compound represented by formula (I) has better pharmacokinetic parameters such as solubility, blood medicine concentration, or half-life period than nitroxoline. The compound represented by formula (I) can reduce the frequency of drug administration, and has potential for application in other fields other than the field of urinary tracts.

Nitroxoline prodrug and use thereof

This invention relates to a method of inhibiting the expression of TNF&#x3b1; or IL-1&#x3b2; with a compound of the following formula: wherein Rand Rare defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.

Andrographolide and analogues as inhibitors of TNF&#x3b1; and IL-1&#x3b2; expression

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Shanghai, China

Ke Pan