Hinova Pharmaceuticals Inc.

Chinese Academy of Sciences

Southwest University of Science and Technology

Ke Chen

Shaohua Zhang

Yuanwei Chen

Xinghai Li

Kexin Xu

Tongchuan Luo

Lei Fan

Xiaoquan Wu

Fei Wang

Wu Du

Yongxu Huo

Geng Sun

Zhilin Tu

Dalin Zhu

Yanbao Lei

Yingxin Xue

The compound of formula (I) has a good inhibitory effect on the proliferation of human prostate cancer cells CWR22RV1 and breast cancer cells; and combined use of the compound with an androgen receptor inhibitor HC-1119 significantly enhances the inhibitory effect on prostate cancer cells, and the inhibitory effect increases with increased concentration. The compound of formula (I) can not only be used independently to prepare an antineoplastic agent but can also be used in combination with other agents having antineoplastic effects, such as an androgen receptor inhibitor, or other targeting drugs etc., to prepare an antineoplastic agent having stronger therapeutic effects, especially an agent for treating prostate cancer and breast cancer.

BRD4 inhibitor as well as a preparative method and use thereof

Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumors, autoimmune or inflammatory diseases and viral infection, and in particular an anti-prostate cancer drug. 

BRD4 inhibitor

An adhesive for moss and a method for preparing the adhesive are provided, wherein the method includes steps of: adding melamine, urea, attapulgite and sepiolite powder into a ball milling tank, and adding milling balls into the ball milling tank for ball milling; then collecting ball-milled materials; adding konjac glucomannan, chitosan and collagen into water and stirring, wherein during stirring, half of the ball-milled materials are added into the water; then adding latex powder, stearic acid and ammonium zirconium carbonate, and stirring, wherein during stirring, the other half of the ball-milled materials are added into the water. The adhesive for moss can be used for bonding moss with sufficient bonding effect, which is environment-friendly and will not harm the moss; meanwhile, the konjac glucomannan, the chitosan, the collagen attapulgite and the sepiolite powder which are contained in the adhesive can provide nutrition for the moss.

Adhesive for moss

Quinoline compounds and salts, hydrates or solvates serving as a selective uric acid reabsorption inhibitor, can be used in the treatment of hyperuricemia and gout by promoting uric acid to excrete from the body and reducing serum uric acid. Such compounds have the effect of reducing the uric acid in the animal body and human body.

Quinoline compounds, preparation methods thereof, and uses thereof as urate transporter inhibitor drug

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Sichuan, China

Ke Chen