Nipro Corporation

Kazuyuki Yamamoto

Toshiya Kai

Makoto Sato

Kazutaka Fujiki

Hiroaki Kato

A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar component is decomposed or colored, and which can maintain stability and is also excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride and a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that is covered with a coating layer comprising the same sugar or a different sugar, and an acid.

Solid preparation for dialysis and process for producing the same

A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.

A one-pack solid pharmaceutical composition for dialysate containing sodium bicarbonate which can prevent the reactions between sodium bicarbonate and acetic acid and between sodium bicarbonate and electrolytes, and is excellent in long term storage stability is provided. The solid pharmaceutical composition for dialysate containing sodium bicarbonate is a mixture of an agent A containing sodium chloride, calcium chloride, magnesium chloride, potassium chloride, sodium acetate and acetic acid and an agent B containing sodium bicarbonate coated with sodium acetate.

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Osaka, Japan

Kazuyuki Yamamoto