Meiji Seika Kaisha, Ltd.

Kazuyuki Fujishima

Kiyoaki Katano

Shuichi Gomi

Keiichi Ajito

Mitsugu Hachisu

Shoichi Murakami

Dai Kubota

Mikio Yamamoto

Minoru Ishikawa

Shokichi Ouchi

Takahiko Satoh

Naokazu Yahata

Tomoko Soneda

Naoko Kamitoh

&OHgr;-amino-&agr;-hydroxycarboxylic acid derivatives having integrin &agr;&ngr;&bgr;3 antagonistic activity

An objective of the present invention is to provide a compound that has antiarrhythmic activity. The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each represent H, halogen or lower alkyl which may be substituted by halogen; A represents H, C3-6 cycloalkyl, phenyl which may be substituted by halogen, nitro, or lower alkoxy, a 5-membered or 6-membered heterocyclic ring which may contain N and/or S, --NR.sup.3 R.sup.4 (wherein R.sup.3 and R.sup.4 each represent H or lower alkyl which may be substituted by phenyl), or COR.sup.5 (wherein R.sup.5 represents OH, amino or lower alkoxy); Q represents S or O; m represents 0-18; and n represents 0-2, and pharmaceutically acceptable salts and solvates thereof.

5-(4-piperidinyl)dibenzothiazepine derivatives and

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Yokohama, Japan

Kazuyuki Fujishima